Norovirus Polymerase Fidelity Contributes to Viral Transmission <i>In Vivo</i>.

The observed lower virus titers and RNA levels in feces of mice infected with I391L were associated with a trend toward lower viral RNA levels in different tissues harvested at 48 h postinoculation, although the differences observed did not reach statistical significance ( Fig. 3D ).Taking the data together, the reduced replication kinetics of the MNV I391L NS7 mutant were apparent only in vivo and not during replication in cell culture.

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Together, these results are highly significant in light of understanding the influence of replication fidelity on factors that affect the emergence of new norovirus variants with pandemic potential.

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