We also tested whether the inhibition of PI3K pathway would modulate the level of PAI-1 by using an inhibitor LY294002 (Cayman Chemical Co, Ann Arbor, MI); however the effect of LY294002 varied among tested chondrocyte samples and the results did not reach statistical significance to conclude the involvement of PI3K pathway (data not shown).
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A suppressive effect of prostaglandin E<sub>2</sub> on the expression of <i>SERPINE1</i>/plasminogen activator inhibitor-1 in human articular chondrocytes: An <i>in vitro</i> pilot study.
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