A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer's disease.

PeerJ · 2016 · PMC5075699 · PMID 27781164

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showed a trendno p-value reported

In a pilot behavioral experiment, ISRIB showed a trend towards enhancement of spatial memory in the Morris water maze Although we did not have a marker of target engagement in the brain for ISRIB, we decided to proceed with a pilot study to test its effects on learning and memory in nontransgenic mice.

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