Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses.

Several adhesion molecules, Tnr, Cadh11, Pcdhgc3, and Sema6d, were also significantly regulated with a clear trend for downregulation in both forms of scaling ( Figure 5 ; Tables S2 and S4 ), reminiscent of earlier studies showing that downregulation of adhesion is required for structural plasticity at synapses ( Mayford et al., 1992 , Schuster et al., 1996 ).

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