showed a trendp = 0.81
In a Danish observational study, 53% of AF patients took more than five drugs/day ( 45 ), while an analysis of the ROCKET AF study showed that 36% of patients were on 0 to 4 medications, 51% were on 5 to 9, 13% were on ≥10; patients taking ≥10 medications daily were older and showed a trend toward a higher bleeding risk (HR 1.46, 95% CI [1.29-1.64], p = 0.81) ( 46 ).