A clear trend was found in the antitrypanosomal potency of nitriles 4a – h regarding the length of the linker, with the potency increasing from n = 5 ( 4a ) to n = 9 ( 4e ), and then decreasing for the longer homologues 4f and 4g .
← all excerpts
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
1
—
—