13 , 29 In our strabismic samples, collagen XII (alpha 1) was increased nearly 4-fold, with strong statistical significance ( Table 1 ), while collagen VI (alpha 3) was increased in one of three sets of experiments with statistical significance, and collagen VI (alpha 2) was increased with borderline significance in that set of experiments ( Supplementary Table S3 ).
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Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons.
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Additional genes with significant changes were the neurotrophin receptors trkA and trkB ( NTRK1 and NTRK2 , up 3- to 4-fold), and neuregulin1 ( NRG1 , down 4-fold), while the reduction of CNTF expression did not reach statistical significance.