Interestingly, the recently published Pan Canadian Rash trial ( 16 ) on the use of minocycline in the management of skin rash caused by erlotinib in lung cancer showed a trend toward improved survival associated with the early use of minocycline (7.6 and 8 months in prophylactic and reactive use) versus if used only when severe rash appears (6 months).
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Minocycline Improves the Efficacy of EGFR Inhibitor Therapy: A Hypothesis.
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