Gray and White Matter Demyelination and Remyelination Detected with Multimodal Quantitative MRI Analysis at 11.7T in a Chronic Mouse Model of Multiple Sclerosis.

Front Neurosci · 2016 · PMC5081351 · PMID 27833528

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did not reach statistical significanceno p-value reported

The smaller amount of myelin contained in the cortex compared to WM drastically decreases the sensitivity of the T 2 w sequence to myelin content changes, explaining why the recovery did not reach statistical significance using T 2 measurements in this limited sample of animals.

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a mild trendno p-value reported

When the neurotoxic agent was removed, a clear improvement of Sr and T 2 value paralleling myelin regeneration on immunohistological samples was found both in the WM and in the deep GM, whereas in S1, only a mild trend to normalization of Sr was detected.

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