ACTH and gonadotropin deficiencies predict mortality in patients treated for nonfunctioning pituitary adenoma: long-term follow-up of 519 patients in two large European centres.

17 , 35 There was a trend towards an increased risk of cerebrovascular death compared to nonirradiated patients, but this did not reach statistical significance.

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In our unselected cohort of consecutive patients with NFPA, we found a highly significant statistical linear trend between the severity of pituitary failure and risk of premature death, with the highest risk observed in those with panhypopituitarism.

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