Both 12h.high-dose treatment groups showed highly significant enrichment of genes mapping to the KEGG pathways: cell cycle, DNA replication and p53 signaling (Table 4 ).
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Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells.
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The sentences
The response after 12 h did not reach statistical significance for any transcript, when CLBL-1 and CLBL-1M were compared, suggesting that the early effects of PDA-66 are similar in both cell lines.