Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels.

The experimental measurements of the corresponding H221L mutation in mouse Kir2.1 channels proved our hypothesis, and the results showed a trend that was similar to that for the mutation from Leu to Ile, which led to faster inhibition dynamics (Fig. 8a, b ) and slower activation dynamics (Fig. 8c, d ).

also in 53,322 other papers