DNA Methylation of PITX2 and PANCR Is Prognostic for Overall Survival in Patients with Resected Adenocarcinomas of the Biliary Tract.

In tumor specimens, intragenic PANCR methylation significantly correlated with PITX2ab (Spearman’s ρ = 0.390; p < 0.001; n = 80) but not PITX2c (Spearman’s ρ = 0.139; p = 0.23; n = 78), whereas PANCR methylation was significantly associated with PITX2c methylation in NAT (Spearman’s ρ = 0.328; p = 0.016; n = 53) but did not reach statistical significance for PITX2ab (Spearman’s ρ = 0.269; p = 0.054; n = 53).

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