Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

This shows that the RC is lower (fewer samples and lower ADAb titre in this model) but continues to be highly significant [RC −3.70 (95% CI: −5.01 to −2.32), P < 0.0001].

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In patients in whom ADAbs were detected using RIA but not ELISA, ADAb levels failed to reach statistical significance independently in association with treatment response.

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