TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

A smaller reduction was seen in patients with FTD‐ALS (12 patients) and behavioral variant FTD (16 patients), which likely suffer from TDP‐43 pathology, although this did not reach statistical significance due to the smaller cohort size.

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We found a highly significant reduction of 43 proteins on the surface, many of them known cargoes of recycling endosomes, while only two surface proteins were significantly upregulated.

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