Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis.

We observed significant associations of rs12212067 genotype with the DAS28, swollen joint count, and CRP level and a nominally significant association with the HAQ score ( P = 0.013, although the stringent bootstrap correction for interindividual correlation meant that the corrected P value was 0.11).

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A nonsignificant trend toward a protective effect of the minor allele at rs12212067, which is consistent with our results, was observed in their meta‐analysis, however, particularly in the cohorts of early RA patients for whom multiple sets of radiographs were available 13 .

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