The sum of gemcitabine and dFdU concentrations in tumor tissues was slightly higher in the AsPC1 + shTG2 xenografts compared with controls but did not reach statistical significance ( Figure 2 D , shCtrl; n = 5 and shTG2; n = 6, P = .4).
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Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer.
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