Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer.

Similarly, using the LDH release assay to evaluate cell membrane integrity, cells infected with AdFAST at an MOI of 1000 showed an almost threefold increase in membrane permeability compared with AdEmpty infected cells at the same MOI, but this effect did not reach statistical significance ( Figure 2e ).

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