Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations.

Results There were five differentially methylated CpG probes significantly associated with COPD among African-Americans at an FDR less than 5 %, and seven additional probes that approached significance at an FDR less than 10 %.

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SERPINA1 is the gene responsible for alpha-1-antitrypsin deficiency, [ 36 ] a known genetic cause of COPD, and this gene was found to be highly significant in the blue module.

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