Blockade of programmed death-1/programmed death ligand pathway enhances the antitumor immunity of human invariant natural killer T cells.

On the other hand, IL-4 production tended to increase in the supernatants following anti-PDL2 antibody-treated APC stimulation; however, it did not reach statistical significance (Fig. 4 b, c). iNKT cell-mediated cytotoxicity toward tumor cell lines Since direct cytotoxicity is one of the important functions of activated iNKT cells, we evaluated the role of anti-PDL1 antibodies in the direct cytotoxic activities of iNKT cells against several tumor cell lines, including lung cancer.

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