Combination therapy of inhaled steroids and long-acting beta2-agonists in asthma-COPD overlap syndrome.

When comparing FEV 1 increase based on the severity of airflow limitation, the ACOS group showed greater improvement than the COPD-alone group in patients with mild-to-moderate airflow limitation (223.2±42.9 vs 84.6±25.3 mL, P =0.005), but the FEV 1 increase did not reach statistical significance in those with severe to very severe airflow limitation (268.2±54.5 vs 197.1±28.4 mL, P =0.209) ( Figure 1A ).

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