A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.

After analysis by SDS–PAGE in the presence of 100 mM DTT, we observed a clear trend toward higher abundance of reduction‐insensitive dimers as a function of a decrease in pH and ionic strength (Fig 2 B).

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A slight trend toward lower binding in the MES buffer could be seen in some experiments, likely attributable to a small pH‐induced conformational change in the actin filaments themselves (Oda et al , 2001 ).

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