Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion.

The difference between significantly down-regulated genes on 22q11.2 compared with the number of significantly differentially expressed genes on the rest of chromosome 22 was highly significant (χ2 test p -value < 2.2e-16).

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One exception is CLDN5 , which also showed larger than 2-fold difference in expression between conditions, but failed to reach statistical significance because of large intragroup variability and relatively lower expression.

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