The gastrocnemius and quadriceps muscles from AAV1- Sirt1 -treated mice showed a trend to express higher levels of the oxidative fiber marker MyHC I when compared with AAV1-Null mice, whereas no differences were observed in the levels of MyHC IIa , MyHC IIb , and MyHC IIx ( Figure 2a , b ).
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AAV-mediated <i>Sirt1</i> overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance.
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