Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2^+/- mice, using liquid chromatography-tandem mass spectrometry.

At 24 h there was also a strong trend to an increase in quinolinic acid levels (P = 0.055).

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3 Results 3.1 Ro61-8048 treatment In the adult pregnant female, the administration of Ro61-8048 produced substantial and highly significant increases in the concentrations of the main kynurenine metabolites of tryptophan in the rat brain.

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There was a tendency for anthranilate levels to be reduced in the mutants, but this did not achieve significance. 3.2.1 Comparison of mouse and rat data Although few direct comparisons have been made of all the brain tryptophan metabolite levels in rat and mouse brains, it was interesting to note that the basal levels of tryptophan (∼35 nmol/g.wet wt), kynurenine (∼0.4 nmol/g.wet wt), xanthurenic acid (∼12 pmol/g.wet wt), anthranilic acid (∼40 pmol/g.wet wt) and quinolinic acid (∼120 pmol/g.wet wt), were comparable in the mice and the untreated adult female rat controls described above.

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