BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.

Nat Commun · 2016 · PMC5116074 · PMID 27845331

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Cox regression analysis of WHO grade IV (GBM) patients divided into BRCA1 low (<14.5%) and BRCA1 high (>14.5%) or RRM2 negative and positive groups showed a trend toward worse survival of BRCA1 high and RRM2 positive patients (251 days for BRCA1 low versus 159 days for BRCA1 high and 320 days for RRM2 negat. versus 148 for RRM2 posit.; Fig. 6d,g , respectively).

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