Genetic variations in the PI3K-PTEN-AKT-mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy.

Sci Rep · 2016 · PMC5120316 · PMID 27876891

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

an obvious trendP = 0.075so close (0.05 < p ≤ 0.1)

As showed in MVA, another two SNPs-AKT1:rs1130214, and mTOR:rs11121704 showed an obvious trend toward inferior DMFS in patients with one or two variant alleles (AKT1:rs1130214 HR = 1.566, 95% CI = 0.956–2.567, P = 0.075; mTOR:rs11121704 HR = 1.655, 95% CI = 0.933–2.935, P = 0.085).

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a clear trendP = 0.075so close (0.05 < p ≤ 0.1)

While AKT2: rs892119 indicated a clear trend to have reduced risk of distant failure when patients carried at least one variant allele (HR = 0.579, 95% CI = 0.317–1.057, P = 0.075).

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