Barely Significant
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Impact of Clinical Trial Results on the Temporal Trends of Carotid Endarterectomy and Stenting From 2002 to 2014.

Stroke · 2016 · PMC5120767 · PMID 27834754

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did not reach statistical significanceP =0.06so close (0.05 < p ≤ 0.1)
a decreasing trendno p-value reported
Primary Analysis A decreasing trend in the rate of carotid endarterectomy was observed after publication of SAPPHIRE in 2004, although this did not reach statistical significance ( P =0.06).

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