HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2.

In keeping with these observations, we found a negative trend for CC genotype frequencies, balanced by an increased trend in TT genotype, in HCV-positive patients compared with BDs (IL28B C/C dominant polymorphism vs IL28B C/T+ IL28B T/T: OR 0.46 p = 0.025, Table 2 ).

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In particular, a positive trend between TLR2 del/del genotype and an increasing risk for HCC (i.e CHC: 4.3%; CIR: 4.9%; HCC: 10.3%) was found; by contrast, the TLR2 del/del prevalence in NHL patients (0.9%) was similar to that found in BDs (1.3%).

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