Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop.

In fact, we found that ChREBP-β overexpression downregulated ChREBP-α mRNA expression ( Figure 3 A) but, in contrast, did not inhibit ChREBP-α promoter activity and even showed a trend towards increased transcriptional activity ( Figure 3 B).

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