Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.

The CHRN Variants May Regulate the Expression of CHRN Genes ( Table 4 ) Cis- eQTL analysis showed that 13 risk SNPs at CHRNB3-CHRNA6 had nominally significant cis- acting regulatory effects on CHRNB3 mRNA expression in cerebellar cortex and thalamus ( p = 0.015–0.022 and 0.026–0.031, respectively), and on CHRNA6 mRNA expression in frontal cortex and hippocampus ( p = 0.042–0.043 and 0.027–0.033, respectively).

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The associations for CHRNA5-A3-B4 were most comprehensively studied and most robust; many of them were highly significant with p values below 10 −72 ; and many of them were detected by high-impact unbiased GWASs.

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