Barely Significant
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Acidity Constant (pK<sub>a</sub> ) Calculation of Large Solvated Dye Molecules: Evaluation of Two Advanced Molecular Dynamics Methods.

Chemphyschem · 2016 · PMC5129556 · PMID 27570194

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a clear trendno p-value reported
For chlorine‐substituted phenols 2 – 4 , a clear trend in the substituent as a function of its position can also be seen.

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