Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.

Although ETC-1002 markedly reduced LDL-C, because Apoe −/− mice carry the majority of their plasma cholesterol in the very-low-density lipoprotein fraction, this effect corresponded to only a modest reduction in total plasma cholesterol of 18% in Apoe −/− mice and 13% in DKO, although the effect did not reach statistical significance in DKO mice ( Fig. 3g ).

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