Autosomal genetic control of human gene expression does not differ across the sexes.

This is consistent with results from the study of the sex-specific genetic architecture of high-level human complex traits [ 26 ], but is in contrast to the observation of a negative relationship in a review of other multiple species, which found that traits with large mean phenotypic differences across the sexes had small or negative genetic correlations [ 16 ]. To test if there was common functionality in the 100 probes with the most nominally significant deviation from r G =1, we performed a gene ontology (GO) analysis using the DAVID functional annotation tool.

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