Consistently with our prior data, whereas the LPS-induced IL-1β increase did not reach statistical significance in WT mice ( P = 0.1), it was significant in Tollip KO mice ( P < 0.001).
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Tollip, an early regulator of the acute inflammatory response in the substantia nigra.
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failed to reach significanceP = 0.17
However, direct comparison of protein abundance between Tollip WT and KO mice failed to reach significance (184 ± 74 pg/mg (Tollip WT) versus 324 ± 55 pg/mg (Tollip KO), P = 0.17, Fig. 2b ).