Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris.

Microb Cell Fact · 2016 · PMC5142404 · PMID 27927205

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

Statistical analysis Difference between groups was analyzed by applying the one-way analysis of variance (ANOVA) with Tukey’s test (P < 0.05 as significant, P < 0.01 as highly significant, P < 0.001 as very highly significant).

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did not reach statistical significanceP > 0.05actually significant

At 10 6.82 IU/mg, the anti-viral activity of IFN-α/Fc-SC was slightly higher than that of IFN-α/Fc-WT, IFN-α/Fc-MD and PEG-IFN-α, but this difference did not reach statistical significance ( P > 0.05).

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