Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques.

There was an interesting trend in which the 10-minute infusion group yielded a different profile than the 1 and 90 minute groups ( e.g. , higher in muscle and heart but lower in brain and lung) but the differences were not significant.

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While there was a trend toward higher IL-6 area under the curves with shorter vector infusion times, these differences did not reach statistical significance.

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