We observed an up-regulation of the expression of several cytokines by IFN-γ-polarized macrophages, including IL-6, IL-8 and IL-12β , and chemokines, such as CXCL3 , CXCL5 , CXCL6 and CXCL11 after CD40L stimulation in the presence of PRL compared with CD40L alone, which did not reach statistical significance, but unlike CD40L stimulation alone, were significantly up-regulated compared with medium ( Fig. 3 B).
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The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation.
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