As expected the MSI-H cancer group had higher proportions of tumours with moderate and pronounced infiltration but this difference did not reach statistical significance (P= 0.287, χ 2 test for trend).
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Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity.
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0.2870
0.2870
The sentences
The novel observation of Heat Shock Protein up-regulation in MSI-H cancer is highly significant in light of the recognised roles of these proteins in innate and antigen-specific immunogenicity.