Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.

Increased activities of PK, and subsequently LDH, could be expected to lead to increased levels of lactate in the WT mice relative to HIF-1α KOs.In Figure 3 A, it can be seen that the decrease in PFK activity in the HIF-1α KOs is correlated with a trend approaching significance ( p = 0.10) toward an increased amount of hexose monophosphates (HMPs), which are pre-PFK glycolytic metabolites, following stimulation of the HIF-1α KO muscle.

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