The observation of a single hypermetabolic image in the mediastinum during FDG-PET did not reach statistical significance as a predictor of mediastinal malignancy (OR 2.34, 95% CI 0.89-6.22), but multiple FDG-PET hypermetabolic lymph nodes were significantly associated with the spread of NSCLC to the mediastinum (OR 3.87, 95% CI 1.40-10.66).
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