Effects of aclidinium on determinants of COPD severity: symptoms and quality of life.

37 Reductions in COPD symptom score were consistently greater with aclidinium than with tiotropium, but these differences did not reach statistical significance. 37 A randomized, double-blind, Phase IIIb study ( NCT01462929 ) compared the bronchodilation efficacy of aclidinium bromide vs tiotropium and vs placebo over a period of 24 hours in patients with moderate-to-severe COPD. 37 Pulmonary function and symptoms were examined in more than 400 patients.

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