CircRNA accumulation in the aging mouse brain.

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

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2a–c ), a strong trend for upregulation that did not reach significance ( Fig. 2a,b - gray circles in bottom right quadrant) was evident.

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