Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy.

PLoS One · 2016 · PMC5156406 · PMID 27973540

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did not reach statistical significanceno p-value reported

In the heart, we saw a trend toward an increase in LC3-I and -II, but this did not reach statistical significance; however, there was a significant increase in the concentration of LC3 mRNA ( Fig 2D ), which could signify a transcriptional response to an unmet need for autophagy [ 23 ].

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