Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans.

PLoS One · 2016 · PMC5156421 · PMID 27973607

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did not reach statistical significanceno p-value reported

In contrary, medication of patients with mild to moderate atherosclerosis with rosuvastatin has been reported to cause an increase of HDL-C as well as plasma-S1P, though the increase in S1P did not reach statistical significance [ 31 ].

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highly significantno p-value reported

The difference in serum-S1P between controls and atherosclerotic patients is highly significant also when PAD and CS patients are analyzed separately ( Fig 1B ).

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