The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

To test the response of FLCN adipKO animals to cold, animals were challenged with acute cold exposure (4°C) followed by measurement of rectal temperature, revealing a strong trend ( P < 0.07) toward resistance to acute temperature drop ( Supplemental Fig. 5F ).

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The relative amount of fat and lean mass, measured by nuclear magnetic resonance (NMR), also did not differ significantly, although a slight trend was noted toward decreased fat mass in the adipKO animals ( Supplemental Fig. 5B ).

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