an increasing trendP = 0.07
In the efficacy group, the LV dimension increased as a function of time as follows: at 4 weeks, Z-scores for MV, AOV, AAO, and isthmus dimensions were significantly greater than those obtained prior to HO therapy (P < 0.01); at 8 weeks, although the MV, AOV, and AAO dimensions demonstrated an increasing trend that did not reach statistical significance (P = 0.07, 0.06, 0.1, respectively), the Z-scores of the isthmus in the three-vessel and trachea view (3VT) views were significantly greater than those obtained at earlier time points (P < 0.05).