These differences did not reach statistical significance. 27 , 42 Comparison between TIO/OLO 5/5 μg and OLO 5 μg monotherapy As in the comparison between once-daily TIO/OLO 5/5 μg FDC and once-daily TIO 5 μg, differences between TIO/OLO 5/5 μg FDC once-daily and OLO 5 μg once-daily, both administered via the Respimat soft-mist inhaler, were generally statistically but not clinically significant in favor of dual bronchodilatation ( Tables 2 and 3 ).
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