Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Mol Psychiatry · 2015 · PMC5189927 · PMID 25349165

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did not reach statistical significanceno p-value reported

A decrease in GAβ was also observed in the lateral entorhinal cortex, visual cortex and CA1 region of the hippocampus, but these changes did not reach statistical significance.

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