A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference.

Results showed that both SNPs that were significantly associated with HC in the two obesity sub‐cohorts exhibited highly significant associations (rs9661614 P = 7.9 × 10 −6 ; rs485660 P = 2.2 × 10 −6 ) that held after correction for multiple testing (rs9661614 FDR‐corrected P = 2.6 × 10 −4 ; rs485660 FDR‐corrected P = 1.4 × 10 −3 ).

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Although rare homozygotes of both rs9661614 and rs485660 showed wider hips than common homozygotes, this increase in HC did not reach statistical significance (Table 3 ).

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